ABSTRACT
Introduction: Leprosy is a chronic granulomatous disease presents variedly depending on the patient's immune status at the time of infection. In this study, we are planning to perform a retrospective analysis to characterise the trend of Lepromatous spectrum of Hansen's disease cases registered in Tertiary care centre. To analyse the incidence,Aim: clinical patterns and variants of Lepromatous spectrum of Hansen's disease cases registered in Tertiary care centre. Objectives: To describe the epidemiological trend of Lepromatous Spectrum of Hansen's Disease and its clinical variants. A Retrospective observational study involving Lepromatous spectrum of Hansen's diseaseMethodology cases registered in leprosy clinic in last 5 years (2017-2021). Patient demographic details, duration of disease, clinical presentations , investigation details like slit skin smear, biopsy reports, treatment data was extracted from the Leprosy case register and data analysis was done in this study. 129 leprosy patients (BL-69, LL-43, Histoid-15, PureResults neuritic-2) reported during the period of 2017 to 2021[ 5 years]. 2018and 2019 had maximum number of cases approximately 30 new cases of leoromatous leprosy . Hypopigmented patches and glove & stocking anaesthesia seen in 59.8% cases, skin nodules seen in 45.7%, earlobe infiltration seen in 21.7%, epistaxis &saddle nose deformity seen in 4.3%, gynaecomastia seen in 2.2%, trophic ulcer seen in 26.1% at the time of presentation mainly involving the foot followed by hands, only nerve involvement without skin lesion present in 1.1% of cases. Claw hand was the most common deformity witnessed . The presence of Wartenberg sign was observed in 10 patients. Apart from ulnar and common peroneal nerve involvement present in 100 %of the patients, other peripheral nerves were involved in significant number of patients.All these patients showed positive acid fast bacilli in slit skin smear . Active surveillanceConclusion and early detection of the disease are imperative to prevent the spread of M. leprae. It is essential for timely implementation of treatment which will prevent deformities and disabilities. Active case detection plays the major role in early diagnosis of leprosy.
ABSTRACT
Background: Tuberculosis is a leading infectious killer disease worldwide. Early diagnosis and prompt treatment on the part of the health care providers is essential for TB control. Their knowledge, attitude and practice have an impact on the tuberculosis patients regarding compliance to treatment and follow up. There are limited studies in India assessing the knowledge of nursing professionals regarding TB transmission, prevention and control. This study seeks to assess the same. Materials and methods: A cross-sectional study was conducted at SRM Medical College and Research Centre, Potheri, Kanchipuram district. A pre-tested self-administered questionnaire was given to 224 nursing staff. The responses were then analyzed. Results: A high proportion (71.80%) of awareness was found regarding the causation of TB by bacterium, air-borne method of spread and over-crowding being a significant risk factor. A lesser proportion of the participants were aware that TB does not spread by breast feeding (54.9%) or hand shaking (33%) and that ATT should be continued during pregnancy. Levels of knowledge on the preventable nature of TB infection (56%) and the availability of ATT were also found to be low. Conclusions: This study indicates the need for addressing the gaps regarding the knowledge and transmission of TB among the nursing care professionals. Nursing professionals still are in need of continuing educational programs regarding treatment and control of TB. Improved knowledge on TB will thus contribute to effective TB control and in the long term, will help India achieve the goal of End TB.
ABSTRACT
Prematurity is the cause of 85% of neonatal morbidity and mortality. Premature rupture of the membranes (PROM) is associated with 30-40% of preterm deliveries. A case-control study conducted between July 2002 and 2003 examined the correlates and risk factors for PROM in Mysore, India. WBCs in vaginal fluid, leucocytes in urine, UTI and infection with E. coli, S. aureus, C. albicans and BV were significantly associated with PROM. BV, E. coli and WBCs in vaginal fluid were independent risk factors. Screening and treatment of BV and E. coli infection in pregnancy may reduce the risk of PROM.
Subject(s)
Case-Control Studies , Female , Fetal Membranes, Premature Rupture/etiology , Humans , India , Infant, Newborn , Infant, Premature , Infant, Premature, Diseases , Leukocytes/cytology , Logistic Models , Multivariate Analysis , Pregnancy , Pregnancy Complications, Infectious/microbiology , Risk Factors , Urinary Tract Infections/complications , Vagina/cytology , Vaginosis, Bacterial/complicationsABSTRACT
A total of 326 high vaginal swabs from infertile women attending the Institute of Reproductive Medicine were cultured from June 1999 to May 2000. Candida species was isolated from 42(12.88%) patients. Candida albicans (40.47%) followed by Candida glabrata (38.09%) were the most common isolates. Other species included Candida tropicalis (14.28%) and Candida krusei (7.14%). All isolates were tested for sensitivity by disc diffusion method on Yeast Nitrogen Agar base towards four antifungals. Seven (16.7%) candida strains showed resistance to Fluconazole and 19(45.23%) of the strains showed resistance to Itraconazole, and 4(9.5%) strains showed resistance to Nystatin. There was no resistance to Amphotericin B. Of the 7 strains resistant to Fluconazole, 3 were Candida krusei, 3 were Candida glabrata and 1 was Candida tropicalis.